The Image and Signal Processing (ISP) Group at the Universitat de València (Spain) develops data analysis techniques and vision algorithms. We focus on methods able to extract knowledge from empirical data drawn by sensory (mostly imaging) systems. These measurements depend on the properties of the scenes and the physics of the imaging process. Our approach to signal, image and vision processing combines machine learning theory with the understanding of the underlying physics and biological vision. Applications mainly focus on computational visual neuroscience and remote sensing data analysis.